These substances promote activation and proliferation of phagocytic cells, such as macrophages, dendritic cells, and apoptotic cells. synthesis of the main information obtained on the subject, which were performed for the preparation of the present study. The research took place in the period from March 27 to April 2, 2021. Synthesis of the data ?Breast milk has diverse benefits for both the nursing mother and the infant. The presence of viral RNA by real-time polymerase chain reaction (RT-PCR) in milk from disease-positive mothers has been detected in a few cases, and infant infections in these conditions suggest oral transmission of maternal or third-party origin. The virulence of the novel coronavirus in human milk is not confirmed, while significant amounts of exclusive antibodies are. Conclusion ?Lactation in the context of COVID-19 has shown greater benefits than risks of vertical transmission. Therefore, it should be encouraged when possible. Keywords: COVID-19, SARS-CoV-2 infection, breastfeeding, vertical infectious disease transmission, immunology Resumo Objetivo ?O presente artigo procura consolidar os conhecimentos existentes sobre o aleitamento materno durante a pandemia do SARS-CoV-2. Fonte de dados ?Foram analisados os artigos de 2020 e 2021 recolhidos dos bancos de dados PubMed, CAPES, Biblioteca Virtual de Sade, Google Scholar, SciELO e bases de dados UpToDate. Livros e documentos governamentais publicados na ltima dcada (2010C2020) tambm foram consultados. Sele??o de estudos ?Dezesseis obras foram utilizadas no presente estudo. A data de publica??o e discuss?o sobre a transmiss?o do SARS-CoV-2 atravs do leite materno foram os critrios de inclus?o. Assim, foram excludos os artigos que continham informa??es repetidas ou sem relevancia para a produ??o. Coleta de dados ?Para a prepara??o do presente estudo, foram realizadas leituras crticas e sntese das principais informa??es obtidas sobre o tema. A pesquisa ocorreu no perodo de 27 de mar?o a 2 de abril de 2021. Sntese dos dados ?O leite materno tem diversos benefcios tanto para a m?e quanto para o lactente. A presen?a de RNA viral por rea??o em cadeia de polimerase em tempo real (RT-PCR, na sigla em ingls) no leite de m?es positivas foi detectada em alguns casos, e as infec??es infantis nestas condi??es sugerem transmiss?o oral de origem materna ou de terceiros. A virulncia do novo coronavrus no leite humano n?o est confirmada, enquanto quantidades significativas de anticorpos exclusivos sim. Conclus?o ?A lacta??o no contexto da COVID-19 mostrou maiores benefcios do que os riscos de transmiss?o vertical. Por conseguinte, deve ser encorajada sempre que possvel. Palavras-chave: COVID-19, infec??o por SARS-CoV-2, aleitamento materno, transmiss?o vertical de doen?as infecciosas, imunologia Introduction In the epilogue of December 2019 and in the advent of the year 2020, the world witnessed the rise of severe acute respiratory syndrome Rabbit polyclonal to PLSCR1 (SARS) caused by a new variant of coronavirus C severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) C which was declared in January 2020 by the World Health Organization (WHO) as an epidemiological pandemic situation. This etiologic agent was responsible for naming a new disease Sodium stibogluconate classification known as Coronavirus disease 2019 (COVID-19), which is considered a public health emergency of international concern (EPII). Moreover, this health condition has become one of the main causes of increased mortality rates, as well as of increased efforts by the most diverse centers of medical practice and research in attempts to understand the disease and its therapeutic approach. 1 In general terms, the clinical manifestations of COVID-19 are variable, a reality that demands great attention from healthcare teams. The most common symptoms of the disease are typical of a flu-like syndrome, and involve cough, fever, dyspnea, myalgia, and, in some cases, abdominal pain and diarrhea. So far, it has Sodium stibogluconate been observed that the disease most frequently affects adults and the elderly, although it is already known that pregnant women, mothers, newborns, and children can also develop it in its aggravating form. However, it is known that the expressivity of these same aspects can be mild and even asymptomatic, although many cases can evolve to severe acute respiratory syndrome, septic shock, and multiple organ failure. 1 2 Sodium stibogluconate In this perspective, the clinical evolution of the disease can be associated to the degree of inflammatory response in the organism of the infected individual, since the higher the degree, the greater the tissue damage and, consequently, the functional compromise of the affected regions. 3 Regarding the transmissibility of the virus, it is.